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The recommended dosage for Andarine typically ranges between 25 to 50 mg per day. One of the most well-known side effects of Andarine is vision disturbances. This can be particularly beneficial for anyone looking to strengthen their skeletal structure while building muscle. Andarine is known for its ability to promote lean muscle mass without causing excessive water retention. Combining two or three SARMs can cause harsher side effects on the HPTA, liver enzymes, and cholesterol levels, as opposed to cycling a single SARM.
Male Sprague Dawley rats were castrated and left alone for 12 weeks to allow maximum decrease in soleus muscle mass and strength to occur. At the time, S4 was the most efficacious SARM in development and revealed some of the most promising preclinical data of a SARM demonstrating potent anabolic effects with less androgenic activity than naturally produced endogenous androgens. Consequently, prostate weight, seminal vesicle weight and muscle weight all plummet in parallel to the crashing androgen levels (hence why low Testosterone in men causes loss of muscle tissue). When an animal is castrated, its endogenous androgen levels plummet because it is no longer capable of producing them through the main mechanism by which the body facilitates it. S4 acts as a full androgen receptor agonist in muscle tissue and a partial agonist in the prostate R. It is less potent in both anabolic and androgenic effects than other SARMs that were developed like Ostarine and LGD-4033. In general, SARMs exhibit much greater androgen receptor specificity, oral bioavailability, and tissue selectivity than steroids.
On the other side of the spectrum, if megadoses of S4 were used daily, it would likely eventually exceed baseline androgenic activity in the body, but this is likely irrelevant for the context in which this compound would hypothetically be used as a treatment anyways. The dosage of S4 that would be required to yield the same amount of androgenic activity in the body that natural endogenous androgens do would be higher than the therapeutic dosage required. In addition, S4 has a high binding affinity at the androgen receptor, meaning it is possible that it could divert Testosterone to aromatize that wouldn't have otherwise, consequently increasing Estrogen levels.
This could lead to improved bone density, providing a solid foundation for your growing muscles. In the fitness world, losing fat while gaining muscle is like striking gold. It wasn’t long before bodybuilders and athletes began using this compound to enhance performance and muscle growth. It wasn’t originally created for bodybuilders or fitness enthusiasts, but as a potential treatment for muscle-wasting diseases. But continuing to increase the dose while vision issues worsen can be dangerous. Always start low (e.g., 25 mg/day split into two doses) and assess tolerance before increasing.
There is no safe dose for this drug since it has not passed proper clinical trials or received approval from any regulatory body. The most frequent user-reported side effects are visual issues such as a yellow tint and difficulty adjusting to night vision. SARMs may even turn out to be more dangerous than many other substances (steroids and testosterone included).
Anecdotally, S4 is reported to exhibit diminishing returns at dosages above 100 mg per day, with 100 mg commonly being referred to as "the sweet spot" dosage. Dosages of 25 – 100 mg per day are commonly used in a recreational context for muscle building purposes. DHT in general is a very poor anabolic agent, and excels only in stimulating androgenic activity in androgen sensitive tissues like the prostate gland and hair follicles. Therefore, in a therapeutic context, SARMs will likely become regarded as the better alternative for inducing anabolism with minimal androgenic activity, but in a supraphysiological bodybuilding context, SARMs will not be building the physiques of any Mr Olympia competitors anytime soon. For those on Testosterone Replacement Therapy however, this can make S23 a potentially more attractive alternative, as it can induce more anabolic activity at lower dosages. While this is favorable for certain therapeutic applications, it makes S23 a poor option for recreational users who are looking to avoid endocrine suppression, or recover after a "cycle" quickly with ease.
S4 is most effective in cutting and recomposition stacks where lean muscle retention and fat loss are priorities. If your cycle exceeds 4 weeks at any dosage, plan to use Clomid or Nolvadex for 4 weeks post-cycle. "Andarine has a short half-life, requiring multiple daily doses to maintain consistent plasma concentrations and reduce peak-related side effects." (Yin et al., Journal of Medicinal Chemistry) Typical S4 doses range from 25–50 mg per day, split into two doses due to the 3–6 hour half-life.
Information provided on personal blogs and commercial websites advises fitness and bodybuilding enthusiasts to supplement with ostarine at dose ranges from 10 mg to 30 mg for at least 12 weeks.17 These doses are 10 times those studied clinically. Andarine is known to cause mild suppression, which means it can potentially interfere with your body’s natural testosterone levels. Most users report that this is a temporary side effect, and normal levels return after the conclusion of the Andarine cycle.

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