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The average male who reaches 70 years old will have testosterone production that’s 30 percent below his peak (5). Younger patients who have a sedentary lifestyle, who aren’t athletic and out running marathons; they don’t need a high level of testosterone. But you don’t have to experience the negative symptoms that come with hormone declines.
Kaeberlein stresses that following a healthy diet and lifting weights have plenty of health benefits, on top of boosting testosterone, so there’s absolutely no harm in trying them. That’s because resistance training, like lifting weights, creates muscle stress, which signals the body to produce more testosterone. The loss of testosterone can also have a significant impact on quality of life for middle-aged men. This is important for both men and women, but men generally lose muscle faster than women as they age. "In the United States, especially for men, hormone health is not typically looked at unless the man asks for it," says Kaeberlein. Kaeberlein says that men who are thinking about their long-term health should be taking their hormones into account. While precise figures aren’t available, Kaeberlein says that, "on average, men experience roughly a 30-50% decline in free testosterone between ages 30 and 70.
…it may be worth getting your levels checked. The goal isn’t just to feel better temporarily—it’s to optimize your health long-term. This allows us to determine, on the spot, whether you’re a candidate for treatment. Testosterone naturally declines with age—but for some men, the drop is more significant. If you’re experiencing several of these symptoms, it may be time to look deeper. Low testosterone (also called "low T") can show up in ways that are easy to overlook.
Research shows that men who exercise regularly have higher testosterone than those who don’t (10). Be sure to speak with your doctor or clinician on which method is best for you and your health needs. However, when you’re undergoing TRT, some people test to determine the peak amount of testosterone, and some people try to grab the trough, says McDevitt. Your testosterone is higher in the morning, so that’s the best time to test. Clinically, if you’re doing well and your doctor agrees that your levels are within good ranges, then you’ll want to test every six months. During the ramp up, you should expect to test every 90 days until your levels get to a good therapeutic state, as determined by your doctor and how you feel.
Aggression should therefore be monitored but in our experience is rarely a significant problem during testosterone replacement producing physiological levels. An increase in self-reported aggressive behaviors have also been reported in one double blind placebo controlled trial of testosterone in young hypogonadal men (Finkelstein et al 1997), but this has not been confirmed in other studies (Skakkebaek et al 1981; O’Connor et al 2002). On the other hand, late onset hypogonadism frequently results in anemia which will then normalize during physiological testosterone replacement. Some patients do not like the feeling of the tablet in the mouth or find that there is an abnormal taste in the mouth, but local adverse effects are usually mild and transient (Wang, Swerdloff et al 2004).
Clav specifically mentions using it to combat "dopamine toxicity." High levels of oxidative stress in the brain can damage dopaminergic neurons. Beta blockers work by blocking the effects of the hormone epinephrine (adrenaline), thereby slowing the heart rate and reducing blood pressure. In a longevity context, exogenous HGH is used to improve skin thickness, increase bone density, reduce body fat, and accelerate recovery from physical stress. Exogenous testosterone suppresses the hypothalamic-pituitary-gonadal (HPG) axis, shutting down the body's natural production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which are required for spermatogenesis. At Total T Clinic, we specialize in personalized hormone therapy to help men reclaim their strength, confidence, and longevity. We provide a holistic approach to men’s health, combining hormone therapy with nutrition, fitness, and lifestyle modifications for maximum results.
A receptor with a short CAG sequence produces greater activity when androgens attach, and men with shorter CAG polymorphisms exhibit androgenic traits, such as preserved bone density (Zitzmann et al 2001) and prostate growth during testosterone treatment (Zitzmann et al 2003). Interpretation of such data requires care, as the presentation of prostate cancer could be altered or delayed in patients with lower testosterone levels. Cross-sectional studies have not shown raised testosterone levels at the time of diagnosis of prostate cancer, and in fact, low testosterone at the time of diagnosis has been linked with more locally aggressive and malignant tumors (Massengill et al 2003; Imamoto et al 2005; Isom-Batz et al 2005). The question of whether testosterone treatment could cause new cases of prostate cancer, or more likely cause progression of undiagnosed histological prostate cancer that would otherwise have remained occult, is an important consideration when treating ageing males with testosterone.
There’s a movement by influencers and early adopters to stack up your level against yourself, not against other people your age. There is a giant reference range regardless of age, so at 70, "normal" remains within a 650-point span. Beware anyone telling you that you, at 30, 40, 50, or even 60, have the testosterone level of a 70-year-old. It’s true that you lose muscle fibers as you get older. —and podcasts and influencers preaching the powers of hormone optimization, should guys over 40 think about winding back their T clocks? But with a boom in testosterone-replacement clinics—by this point, who hasn’t gotten an ad for a service offering to test your T for under $100? And, of course, your testosterone level drops.

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